Investigation of Morphometric Variability of Subthalamic Nucleus, Red Nucleus, and Substantia Nigra in Advanced Parkinson's Disease Patients Using Automatic Segmentation and PCA-Based Analysis
Identifieur interne : 000089 ( France/Analysis ); précédent : 000088; suivant : 000090Investigation of Morphometric Variability of Subthalamic Nucleus, Red Nucleus, and Substantia Nigra in Advanced Parkinson's Disease Patients Using Automatic Segmentation and PCA-Based Analysis
Auteurs : YIMING XIAO [Canada] ; Pierre Jannin [France] ; Tiziano D'Albis [France] ; Nicolas Guizard [Canada] ; Claire Haegelen [France] ; Florent Lalys [France] ; Marc Verin [France] ; D. Louis Collins [Canada]Source :
- Human brain mapping [ 1065-9471 ] ; 2014.
Descripteurs français
- Pascal (Inist)
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English descriptors
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Abstract
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective surgical therapy to treat Parkinson's disease (PD). Conventional methods employ standard atlas coordinates to target the STN, which, along with the adjacent red nucleus (RN) and substantia nigra (SN), are not well visualized on conventional Tlw MRIs. However, the positions and sizes of the nuclei may be more variable than the standard atlas, thus making the pre-surgical plans inaccurate. We investigated the morphometric variability of the STN, RN and SN by using label-fusion segmentation results from 3T high resolution T2w MRIs of 33 advanced PD patients. In addition to comparing the size and position measurements of the cohort to the Talairach atlas, principal component analysis (PCA) was performed to acquire more intuitive and detailed perspectives of the measured variability. Lastly, the potential correlation between the variability shown by PCA results and the clinical scores was explored.
Affiliations:
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first="Florent" last="Lalys">Florent Lalys</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM, U1099</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université de Rennes 1, LTSI</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" 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aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Jannin, Pierre" sort="Jannin, Pierre" uniqKey="Jannin P" first="Pierre" last="Jannin">Pierre Jannin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM, U1099</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université de Rennes 1, LTSI</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author><author><name sortKey="D Albis, Tiziano" sort="D Albis, Tiziano" uniqKey="D Albis T" first="Tiziano" last="D'Albis">Tiziano D'Albis</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM, U1099</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université de Rennes 1, LTSI</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author><author><name sortKey="Guizard, Nicolas" sort="Guizard, Nicolas" uniqKey="Guizard N" first="Nicolas" last="Guizard">Nicolas Guizard</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University</s1><s2>Montreal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM, U1099</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université de Rennes 1, LTSI</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Service de Neurochirurgie, CHU Pontchaillou</s1><s2>Rennes</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Lalys, Florent" sort="Lalys, Florent" uniqKey="Lalys F" first="Florent" last="Lalys">Florent Lalys</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM, U1099</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Université de Rennes 1, LTSI</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Neurology Department, University Hospital Rennes</s1><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>University Hospital Rennes</wicri:noRegion><wicri:noRegion>Neurology Department, University Hospital Rennes</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>EA 4712 "Behavior and Basal Ganglia", Rennes 1 University</s1><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Rennes 1 University</wicri:noRegion><wicri:noRegion>EA 4712 "Behavior and Basal Ganglia", Rennes 1 University</wicri:noRegion></affiliation></author><author><name sortKey="Collins, D Louis" sort="Collins, D Louis" uniqKey="Collins D" first="D. Louis" last="Collins">D. Louis Collins</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University</s1><s2>Montreal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author></analytic><series><title level="j" type="main">Human brain mapping</title><title level="j" type="abbreviated">Hum. brain mapp.</title><idno type="ISSN">1065-9471</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Human brain mapping</title><title level="j" type="abbreviated">Hum. brain mapp.</title><idno type="ISSN">1065-9471</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Advanced stage</term><term>Atlas</term><term>Automatic analysis</term><term>Deep brain stimulation</term><term>Human</term><term>Image processing</term><term>Locus niger</term><term>Morphometry</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Principal component analysis</term><term>Radiodiagnosis</term><term>Red nucleus</term><term>Segmentation</term><term>Subthalamic nucleus</term><term>Variability</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Morphométrie</term><term>Variabilité</term><term>Noyau sousthalamique</term><term>Noyau rouge</term><term>Locus niger</term><term>Stade avancé</term><term>Homme</term><term>Analyse automatique</term><term>Segmentation</term><term>Traitement image</term><term>Atlas</term><term>Analyse composante principale</term><term>Radiodiagnostic</term><term>Stimulation cérébrale profonde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Atlas</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective surgical therapy to treat Parkinson's disease (PD). Conventional methods employ standard atlas coordinates to target the STN, which, along with the adjacent red nucleus (RN) and substantia nigra (SN), are not well visualized on conventional Tlw MRIs. However, the positions and sizes of the nuclei may be more variable than the standard atlas, thus making the pre-surgical plans inaccurate. We investigated the morphometric variability of the STN, RN and SN by using label-fusion segmentation results from 3T high resolution T2w MRIs of 33 advanced PD patients. In addition to comparing the size and position measurements of the cohort to the Talairach atlas, principal component analysis (PCA) was performed to acquire more intuitive and detailed perspectives of the measured variability. Lastly, the potential correlation between the variability shown by PCA results and the clinical scores was explored.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Québec</li><li>Région Bretagne</li></region><settlement><li>Montréal</li><li>Rennes</li></settlement><orgName><li>Université McGill</li><li>Université de Rennes 1</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Yiming Xiao" sort="Yiming Xiao" uniqKey="Yiming Xiao" last="Yiming Xiao">YIMING XIAO</name></region><name sortKey="Collins, D Louis" sort="Collins, D Louis" uniqKey="Collins D" first="D. Louis" last="Collins">D. Louis Collins</name><name sortKey="Guizard, Nicolas" sort="Guizard, Nicolas" uniqKey="Guizard N" first="Nicolas" last="Guizard">Nicolas Guizard</name></country><country name="France"><region name="Région Bretagne"><name sortKey="Jannin, Pierre" sort="Jannin, Pierre" uniqKey="Jannin P" first="Pierre" last="Jannin">Pierre Jannin</name></region><name sortKey="D Albis, Tiziano" sort="D Albis, Tiziano" uniqKey="D Albis T" first="Tiziano" last="D'Albis">Tiziano D'Albis</name><name sortKey="D Albis, Tiziano" sort="D Albis, Tiziano" uniqKey="D Albis T" first="Tiziano" last="D'Albis">Tiziano D'Albis</name><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><name sortKey="Jannin, Pierre" sort="Jannin, Pierre" uniqKey="Jannin P" first="Pierre" last="Jannin">Pierre Jannin</name><name sortKey="Lalys, Florent" sort="Lalys, Florent" uniqKey="Lalys F" first="Florent" last="Lalys">Florent Lalys</name><name sortKey="Lalys, Florent" sort="Lalys, Florent" uniqKey="Lalys F" first="Florent" last="Lalys">Florent Lalys</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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